Session 6: Integrative analyses and Mendelian Randomization

session overview

• Integrative Methods
  • Transcriptome-Wide Association Studies (TWAS)
  • Resources
  • Other “-WAS” Approaches
  • Example Applications in Practice
• Mendelian Randomization
  • Basic theory of Mendelian randomization
  • Robust methods for Mendelian randomization analysis
  • Software and resources

Suggested Readings

• Mai, J., Lu, M., Gao, Q. et al. Transcriptome-wide association studies: recent advances in methods, applications and available databases. Commun Biol 6, 899 (2023). [https://doi.org/10.1038/s42003-023-05279-y]

• Wainberg, M., Sinnott-Armstrong, N., Mancuso, N. et al. Opportunities and challenges for transcriptome-wide association studies. Nat Genet 51, 592–599 (2019). [https://doi.org/10.1038/s41588-019-0385-z]

• Sanderson, E., Glymour, M. M., Holmes, M. V., Kang, H., Morrison, J., Munafò, M. R., Palmer, T., Schooling, C. M., Wallace, C., Zhao, Q., & Davey Smith, G. (2022). Mendelian randomization. Nature Reviews Methods Primers, 2(1), 1–21. https://doi.org/10.1038/s43586-021-00092-5